Clinical Studies

Impedance Cardiography (ICG) has been the subject of hundreds of articles and clinical studies. The BioZ® ICG System has been clinically proven, both in rigorous clinical trials and by current user validation. A comprehensive list of over 500 ICG studies is available at www.impedancecardiography.com.

Click to view the PREDICT article
Journal of the American College
of Cardiology

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Utility of Impedance Cardiograpy for the Identification of Short Term Risk of Clinical Decompensation in Stable Patients with Chronic Heart Failure
 
Click to view the results of
the Mayo Clinic’s resistant
hypertension article in
Hypertension.
Download your free copy.
Resistant Hypertension: Comparing Hemodynamic Management to Specialist Care
 
Click to view the CONTROL article
in Hypertension.

* Note: Hypertension requires a quick plug-in download to view this PDF file
Value of Noninvasive Hemodynamics to Achieve Blood Pressure Control in Hypertensive Subjects

Summaries of significant clinical studies and articles on BioZ ICG are provided in the following categories:

Accuracy
Reproducibility
Heart Failure
Dyspnea
Hypertension
Pacemaker
Emergency
Critical Care
Technology

The following references are listed as a professional courtesy. This does not constitute an endorsement of products or services by the authors of the referenced studies.

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Accuracy

Title:

Equivalence of Bioimpedance and Thermodilution in Measuring Cardiac Index After Cardiac Surgery.

J Cardiothorac Vasc Anesth. 2002;16(1):8-14.

Authors:

Sageman WS, Riffenburgh RH, Spiess BD.

Title:

Impedance Cardiography: The Next Vital Sign Technology?

Chest. 2003;123(6):2028-2033.

Authors:

Van De Water JM, Miller TW, et al.

Title:

Equivalence of the Bioimpedance and Thermodilution Methods in Measuring Cardiac Output in Hospitalized Patients with Advanced, Decompensated Chronic Heart Failure

Am J Crit Care. 2004;13(6):469-479.

Authors:

Albert N, Hail M, Li J, Young JB.

Title:

Noninvasive Cardiac Index Using Bioimpedance in Comparison to Direct Fick and Thermodilution Methods in Patients with Pulmonary Hypertension.

Chest. 1999;116(4):281S.

Authors:

Yung GL, Fletcher CC, Fedullo PF, Johnson FW, Kinninger K, Knowlton KU, Channick RN.

Title:

Comparison of Impedance Cardiography with Invasive Hemodynamic Measurements in Patients with Heart Failure Secondary to Ischemic or Nonischemic Cardiomyopathy.

Am J Cardiol. 2002;89(8):993-5.

Authors:

Drazner M, Thompson B, Rosenberg P Kaiser P, Boehrer J, Baldwin B, Dries D, and Yancy C.

Title:

Comparison of Cardiac Output Measurements by TEB vs. Intermittent Bolus Thermodilution in Mechanical Ventilated Patients.

Chest. 1999;116(4):281S.

Authors:

Ziegler D, Grotti L, Krucke G.

Title:

Comparative Overview of Cardiac Output Measurement Methods: Has Impedance Cardiography Come of Age?

Congest Heart Fail. 2000;6(2):7-18.

Authors:

DeMaria AN, Raisinghani A.

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Reproducibility

Title:

Impedance Cardiography: The Next Vital Sign Technology?

Chest. 2003;123(6):2028-2033.

Authors:

Van De Water JM, Miller TW, et al.

Title:

Reproducibility of Impedance Cardiography Parameters in Outpatients with Clinically Stable Coronary Artery Disease.

Am J Hypertens 2005;18(2):44S-50S.

Authors:

Treister N, Wagner K, Jansen PR.

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Heart Failure - Review

Title:

Beyond the Four Quadrants: The Critical and Emerging Role of Impedance Cardiography in Heart Failure.

Congest Heart Fail. 2004;10(2 suppl 2):1-6.

Authors:

Strobeck JE, Silver MA.

Title:

Noninvasive Hemodynamic Monitoring in Heart Failure: Utilization of Impedance Cardiography (ICG)

Congest Heart Fail. 2003:9(5):241-250

Authors:

Yancy C, Abraham W.

Title:

Impedance Cardiography: A Bridge Between Research and Clinical Practice in the Treatment of Heart Failure.

Congest Heart Fail. 2000;6(2):40-47.

Authors:

Ventura HO, Pranulis MF, Young C, Smart FW.

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Heart Failure - Diagnostic

Title:

Is Impedance Cardiograph-Derived Systolic Time Ratio a Useful Method to Determine Left Ventricular Systolic Dysfunction in Heart Failure?

J Card Fail. 2004;10(4 suppl):S38.

Authors:

Thompson B, Drazner M, Dries D, Yancy C.

Title:

Comparison of Changes in Ejection Fraction to Changes in Impedance Cardiography Cardiac Index and Systolic Time Ratio.

Congest Heart Fail. 2004;10(2 suppl 2):11-13.

Authors:

Parrott CW, Burnham KM, Quale C, Lewis DL.

Title:

Impedance Cardiography in Heart Failure Patients in the Intensive Care Unit: Its Value in the Detection of Left Ventricular Systolic Dysfunction and Correlation with the Echocardiogram.

J Am Coll Cardiol. 2004;43(5 Suppl A):207A

Authors:

Ramirez M, Marians C, et al.

Title:

A Word Salad in the Treatment of CHF: BVA, ICG, BNP.

J Card Fail. 2005;11(6 Suppl):S201.

Authors:

Schnitzler R, Paparelli V.

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Heart Failure - Prognostic

Title:

Utility of Impedance Cardiography for the Identification of Short-Term Risk of Clinical Decompensation in Stable Patients With Chronic Heart Failure.

J Am Coll Cardiol. 2006;47:2245-2252.

Authors:

Packer M, Abraham W, Mehra M, Yancy C, Lawless C, et al.

Title:

B-Type Natriuretic Peptide and Impedance Cardiography Testing at the Time of Routine Echocardiography Predict Subsequent Heart Failure Events.

J Card Fail. 2005;11(suppl 6):S123.

Authors:

Castellanos L, Bhalla V, Isakson S, Bhalla M, et al.

Title:

Association of Impedance Cardiography Parameters with Changes in Functional and Quality-of-Life Measures in Patients with Chronic Heart Failure.

Congest Heart Fail. 2004;10(2 suppl 2):22-27.

Authors:

Vijayaraghavan K, Crum S, Cherukuri S, Barnett-Avery L.

Title:

Use of Systolic Time Ratio and B-type Natriuretic Peptide to Predict Mortality in Patients with Heart Failure.

J Card Fail. 2003;9(suppl):S105.

Authors:

Zewail A, Broom C, Delgado R.

Title:

Combination of B-type Natriuretic Peptide Levels and Non-Invasive Hemodynamic Parameters in Diagnosing Congestive Heart Failure in the Emergency Department.

Cong Heart Fail. 2004;10:171-176.

Authors:

Barcarse E, Kazanegra R, Chen A, Clopton P, Maisel A.

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Heart Failure - Theraputic

Title:

Use of Noninvasive Hemodynamics to Aid Decision Making in the Initiation and Titration of Neurohormonal Agents.

Congest Heart Fail. 2004;10(2 suppl 2):28-31.

Authors:

Summers RL, Parrott CW, Quale C, Lewis DL.

Title:

Effects of Carvedilol on Heart Rate and Blood Pressure Variability in Subjects with Chronic Heart failure.

Am J Card. 2000;86:1392-1395.

Authors:

Piccirillo G, Luparini R, et al.

Title:

Safety and Efficacy of Intermittent, Short-Term, Outpatient Nesiritide Infusions for the Treatment of Decompensated Heart Failure.

J Card Fail. 2003;9(suppl):S68.

Authors:

Mulki G, Pisano C Silver M, et al.

Title:

Intermittent Milrinone and Beta Blocker Therapy: Hemodynamic (Bioz.com) Indicators of Successful Weaning from Inotropes.

J Card Fail. 2000;6(3):73.

Authors:

Choudhary G, Fayn E, Vrushab R, Kumbar C, Antonio C, Just V, Clark WA, Papp MA.

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Dyspnea

Title:

Impact of Impedance Cardiography on Diagnosis and Therapy of Emergent
Dyspnea: The ED-IMPACT Trial

Academic Emergency Medicine. 2006;13:365-371.

Authors:

Peacock WF, Summers RL, Vogel J, Emerman CE.

Title:

Utility of Impedance Cardiography to Determine Cardiac vs. Noncardiac Cause of Dyspnea in the Emergency Department.

Congest Heart Fail. 2004;10(2 suppl 2):14-16.

Authors:

Springfield C, Sebat F, Johnson D, Lengle S, Sebat C.

Title:

The Clinical Utility of Impedance Cardiography in Diagnosing Congest Heart Failure in Dyspneic Emergency Department Patients.

Acad Emerg Med. 2002;9(5):439-440.

Authors:

Han J, Lindsell C, Tsurov B, Storrow A.

Title:

Utility of Impedance Cardiography for Dyspneic Patients in the ED

AmJ of Emerg Med. 2007;25:437-441.

Authors:

Lo H, Liao S, Ng C, Kuan J, Chen J, Chiu T.

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Hypertension

Title :

Resistant Hypertension: Comparing Hemodynamic Management to Specialist Care.

Hypertension. 2002;39:982-988.

Authors:

Taler SJ, Textor SC, Augustine JE.

Title:

Value of noninvasive hemodynamics to achieve blood pressure control in hypertensive subjects.

Hypertension. 2006;47:769-775.
Note: Hypertension requires a quick plug-in download to view this PDF file.

Authors:

Smith R, Levy P, Ferrario C.

Title

:

Editorial accompanying the CONTROL original paper

Noninvasive hemodynamic measurements: An important advance in individualizing
drug therapies for hypertensive patients.

Hypertension. 2006;47:769-775.
Note: Hypertension requires a quick plug-in download to view this PDF file.

Authors:

Flack JM.

Title

Cost-Effectiveness of Impedance Cardiography Testing in Uncontrolled Hypertension

Am Heart Hosp J. 2006;4:279-289.

Authors:

Ferrario C, Smith R; for the CONTROL Trial Investigators

Title:

Improvement in Blood Pressure Control with Impedance Cardiography-Guided Pharmacologic Decision Making.

Congest Heart Fail. 2004;10:54-58.

Authors:

Sharman DH, Gomes CP, Rutherford JP.

Title:

A Hemodynamic Approach to Resistant Hypertension.

Congest Heart Fail. 2000;6(2):36-39.

Authors:

Taler SJ, Augustine J, Textor SC.

Title:

Hemodynamic and Volume Changes During Intensive Treatment (Rx) for Resistant Hypertension (ResHTN).

Am J Hypertens. 2000;13(4):61A-62A.

Authors:

Taler SJ, Augustine J, Burnett JC, Textor SC.

Title:

Normohemodynamic Goal-Oriented Antihypertensive Therapy Improves the Outcome.

Am J Hypertens. 1996;9(4):141A.

Authors:

Sramek BB, Tichy JA, Hojerova M, Cervenka V.

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Pacemaker

Title:

Impedance Cardiography for Atrioventricular Interval Optimization During Permanent Left Ventricular Pacing.

PACE. 2003;26(Pt. II)189-191.

Authors:

Tse H, Yu C, Park E, Lau C.

Title:

Impedance Cardiography for Acute Pacing AV Optimization.

J Card Fail. 2001;7(3 suppl 2):52.

Authors:

Johnson WB, Voegtlin L, Bailin S, Hoyt R.

Title:

Atrioventricular Interval Optimization After Biventricular Pacing: Echo/Doppler vs. Impedance Plethysmography.

Pacing Clin Electrophysiol. 2000;23(4):590.

Authors:

Hayes DL, Hayes SN, Hyberger LK, Trusty JM, Klein S, Hagen ME, Hodge DO.

Title:

Atrioventricular Interval Optimization Technique: Impedance Measurements vs. Echo/Doppler.

Pacing Clin Electrophysiol. 1998;21(4):969.

Authors:

Hayes DL, Hayes SN, Hyberger LK.

Title:

Noninvasive Hemodynamic Monitorization for AV Interval Optimization in Patients with Ventricular Resynchronization Therapy.

Rev Port Cardiol. 2003;(9):1091-8.

Authors:

Santos JF, Parreira L, Madeira J, Fonseca N, Soares LN Ines L.

Title:

Difficult Cases in Heart Failure.

Congest Heart Fail. 1999;5:235-237.

Authors:

Silver MA, Ventura HO.

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Emergency

Title:

Impact of Impedance Cardiography on Diagnosis and Therapy of Emergent
Dyspnea: The ED-IMPACT Trial

Academic Emergency Medicine. 2006;13:365-371.

Authors:

Peacock WF, Summers RL, Vogel J, Emerman CE.

Title:

Utility of Impedance Cardiography to Determine Cardiac vs. Noncardiac Cause of Dyspnea in the Emergency Department.

Congest Heart Fail. 2004;10(2 suppl 2):14-16.

Authors:

Springfield C, Sebat F, Johnson D, Lengle S, Sebat C.

Title:

Combination of B-Type Natriuretic Peptide Levels and Non-Invasive Hemodynamic Parameters in Diagnosing Congestive Heart Failure in the Emergency Department.

Congest Heart Fail. 2004;10:171-6.

Authors:

Barcarse E, Kazanegra R, Maisel A, et al.

Title:

Occult Perfusion Deficit in Heart Failure Patients: Identification Through Noninvasive Central Hemodynamic Monitoring.

Crit Care Med. 1999;27(12):A88.

Authors:

Milzman DP, Morrisey J, Pugh C, Napoli A, Gerace T, Fernandez E.

Title:

Utility of Impedance Cardiography for Dyspneic Patients in the ED

AmJ of Emerg Med. 2007;25:437-441.

Authors:

Lo H, Liao S, Ng C, Kuan J, Chen J, Chiu T.

Title:

The Clinical Utility of Impedance Cardiography in Diagnosing Congest Heart Failure in Dyspneic Emergency Department Patients.

Acad Emerg Med. 2002;9(5):439-440.

Authors:

Han J, Lindsell C, Tsurov B, Storrow A.

Title:

Bioimpedance Monitoring: Better Than Chest X-ray for Predicting Abnormal Pulmonary Fluid?

Congest Heart Fail. 2000;6(2):32-35.

Authors:

Peacock WF, Albert NM, Kies P, White RD, Emerman CL.

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Critical Care

Title:

Evaluation of Impedance Cardiography as an Alternative to Pulmonary Artery Catheterization in Critically Ill Patients.

Congest Heart Fail. 2004;10(2 suppl 2):17-21.

Authors:

Silver M, Cianci P, Brennan S, Longeran-Thomas H, Ahmad F.

Title:

Bioimpedance Cardiography Measurements of Cardiac Output and Other Measurements.

Crit Care Clin No Am 2006;18:195-202.

Authors:

Albert N.

Title:

Invasive and Noninvasive Hemodynamic Monitoring of Acutely Ill Sepsis and Septic Shock Patients in the Emergency Department.

Eur J Emerg Med. 2000;7:169-175.

Authors:

Shoemaker W, Wo C, et al.

Title:

Utility and Economic Benefit of Thoracic Bioimpedance in Critical Care Patients.

J Card Fail. 1999;1(5)

Authors:

Ahmad F, Parvathaneni L, Silver MA.

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Technology

Title:

The Historical Evolution of Bioimpedance.

AACN Clinical Issues. 1999;10(3):371-384.

Authors:

Tsadok S.

Title:

Electrophysiologic Principles and Theory of Stroke Volume Determination by Thoracic Electrical Bioimpedance.

AACN Clinical Issues. 1999;10(3):385-399.

Authors:

Osypka MJ, Bernstein DP.

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